The song was used in an advert for KFC in the United Kingdom.

The song was featured in the third episode of Euphoria.

A version of the song was used in a Chex commercial titled 'Chex Gon' Give It To Ya'.

The song was featured in episode 7 of the seventh season of Shameless.

In early 2019 the song was widely featured in memes and videos associated with the popular character Mr X in the 2019 remake of Resident Evil 2 at the time the game came out on the same day DMX was released from prison on January 25, 2019.

The song was featured on the soundtrack of the 2016 video game Forza Horizon 3.

As it became closely associated with the franchise, it briefly played in the sequel, Deadpool 2 (2018).

The song was featured in the 2016 Marvel Comics movie Deadpool, and appears on its official soundtrack.

The song was used in the trailer of The Brave One.

The song was featured in the 9th episode of the Adult Swim television show Rick and Morty named ' Something Ricked This Way Comes'.

'X Gon' Give It to Ya' has been used as the walk-up song of former San Diego Padres outfielder Xavier Nady and Boston Red Sox infielder Xander Bogaerts, as well as the walkout song of MMA fighter Brian Ortega.

The song was featured in the 2003 video game Def Jam Vendetta, in which DMX is also a character.

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